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Polygenic and polysocial risk scores in post-type 2 diabetes dementia: Risk stratification and predictive modeling in the UK Biobank cohort.

Journal of Alzheimer's disease : JAD - 1 May 2026

He Nan, Wu Hongguang, An Nan, Bu Jin, Li Yiran, Dai Yaqi, Ou Yanqiu, He Feiying

Abstract excerpt

BackgroundDementia is a common complication of type 2 diabetes mellitus (T2DM), influenced by both genetic susceptibility and social disadvantages. While polygenic risk scores (PRS) have been widely applied to assess genetic vulnerability, the contribution of social determinants and their interaction with genetic risk are less understood.ObjectiveThis study aimed to investigate the independent and joint effects...

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PMID: 41910452
DOI: 10.1177/13872877261435200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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