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Article

The association of Alzheimer's disease genetic risk with social connectedness in middle- and older ages.

American journal of epidemiology - 17 Mar 2026

Zimmerman Scott C, Chen Ruijia, Thoma Mary, Pacca Lucia, Hebert Jillian, Riley Alicia, Kim Min Hee, Pederson Annie, Yang Yulin, Buto Peter, Brenowitz Willa D, Glymour M Maria, Kotwal Ashwin, Torres Jacqueline M

Abstract excerpt

Observational evidence suggests that social connectedness protects against Alzheimer's disease (AD), but reverse causality has not been ruled out. We evaluated the potential for a reverse path by estimating associations between AD genetic risk score (AD-GRS) and social connectedness across mid and late-life. We used data from 487 194 UK Biobank participants aged 40+ years and considered social connectedness...

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Identifiers

PMID: 40512627
DOI: 10.1093/aje/kwaf122
PMCID: PMC13066336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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