Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms

7 May 2019

Abstract excerpt

Abstract Ph-negative myeloproliferative neoplasms (MPNs) are hematological cancers that can be subdivided into entities with distinct clinical features. Somatic mutations in JAK2, CALR, and MPL have been described as drivers of the disease, together with a variable landscape of nondriver mutations. Despite detailed knowledge of disease mechanisms, targeted therapies effective enough to eliminate MPN cells are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Eosinophilic Disorders and Syndromes
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31064751
DOI: 10.1182/blood.2019000519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasmsPMID 31064751Read ↗

Targeted cancer exome sequencing reveals recurrent mutations in myeloproliferative neoplasmsSemantic proximity Read ↗

Impact of molecular profiling on the management of patients with myelofibrosis.Semantic proximity Read ↗

Targeted deep sequencing in primary myelofibrosisSemantic proximity Read ↗

Molecular characterization of triple-negative myeloproliferative neoplasms by next-generation sequencing.Semantic proximity Read ↗

Broad Next-Generation Integrated Sequencing of Myelofibrosis Identifies Disease-Specific and Age-Related Genomic Alterations.Semantic proximity Read ↗

Targeted next-generation sequencing using a multigene panel in myeloid neoplasms: Implementation in clinical diagnostics.Semantic proximity Read ↗

Is it the time to integrate novel sequencing technologies into clinical practice?Semantic proximity Read ↗

Myelofibrosis: Genetic Characteristics and the Emerging Therapeutic Landscape.Semantic proximity Read ↗

Genomic landscape of neutrophilic leukemias of ambiguous diagnosisSemantic proximity Read ↗

Transcriptional configurations of myeloproliferative neoplasms.Semantic proximity Read ↗

Driver mutation landscape of acute myeloid leukemia provides insights for neoantigen-based immunotherapy.Semantic proximity Read ↗

Myeloid somatic mutation panel testing in myeloproliferative neoplasms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.