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Nerve-to-cancer transfer of mitochondria during cancer metastasis

25 Jun 2025

Abstract excerpt

The nervous system has a pivotal role in cancer biology, and pathological investigations have linked intratumoural nerve density to metastasis1. However, the precise impact of cancer-associated neurons and the communication channels at the nerve–cancer interface remain poorly understood. Previous cancer denervation models in rodents and humans have highlighted robust cancer dependency on nerves, but the...

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PMID: 40562940
DOI: 10.1038/s41586-025-09176-8

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