Article

Mechanical cues of extracellular matrix determine tumor innervation

2024-03-28

Abstract excerpt

Peripheral tumors can establish local autonomic and sensory nerve networks, termed as tumor innervation (TIN), to support tumorigenesis and metastasis. While nerve dependence in cancers is well-established, the mechanisms governing TIN remain unclear. Here, we report that extracellular matrix (ECM) stiffness, a major mechanical abnormality in the tumor microenvironment (TME), is an essential contributor of TIN. In...

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Literature Corpus work: 9947bf84-3a5b-5860-97f0-4c5b126f1381
DOI: 10.1101/2024.03.25.586535

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