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Article

Perioperative polygenic and APOE-based genetic risk assessment for neurocognitive disorders: a biobank study.

British journal of anaesthesia - 1 Apr 2026

Thedim Mariana, Hu Jie, Maher Matthew, Wiener-Kronish Jeanine, Saxena Richa, Vacas Susana

Abstract excerpt

BACKGROUND: Preoperative risk assessment is a critical step in developing targeted preventive and therapeutic strategies. Although genetic biomarkers have shown considerable promise in assessing and stratifying dementia risk, their application in the perioperative period remains unexplored. Given the recognised effects of surgery and anaesthesia on perioperative cognitive trajectories, this study aimed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40562635
DOI: 10.1016/j.bja.2025.05.014
PMCID: PMC13168963

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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