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Article

Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury.

Anesthesiology - 1 Apr 2010

McDonagh David L, Mathew Joseph P, White Willam D, Phillips-Bute Barbara, Laskowitz Daniel T, Podgoreanu Mihai V, Newman Mark F

Abstract excerpt

BACKGROUND: Postoperative cognitive dysfunction (POCD) is a significant cause of morbidity after noncardiac surgery. Identified risk factors are largely limited to demographic characteristics. We hypothesized that POCD was associated with apolipoprotein E4 (APOE4) genotype and plasma biomarkers of brain injury and inflammation. METHODS: Three hundred ninety-four patients older than 55 yr undergoing major elective...

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Identifiers

PMID: 20216394
DOI: 10.1097/ALN.0b013e3181d31fd7
PMCID: PMC2933423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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