Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A demethylation-driven gene signature predicts prognosis and therapeutic vulnerability in hepatocellular carcinoma.

Scientific reports - 26 Feb 2026

Wang Zhengwei, Shi Lei, Li Yongjian, Liu Sikai, Shi Wanyin

Abstract excerpt

To develop and validate a demethylation-driven gene signature for predicting HCC prognosis, immune microenvironment features, and therapeutic vulnerabilities. We integrated transcriptomic data from TCGA-LIHC (n = 346 tumors) and GEO-GSE112790 (n = 183 tumors) with a curated list of 3,743 demethylation-related genes (DRGs). Tumor-associated DRGs were identified via differential expression analysis and WGCNA. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

Share to Transcriptome

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 41748810
DOI: 10.1038/s41598-026-41443-0
PMCID: PMC13046747

Genes

G6PD
CDC20
CEP41
SPINDOC
SUB1
TP53
VPS72

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A demethylation-driven gene signature predicts prognosis and therapeutic vulnerability in hepatocellular carcinoma.PMID 41748810Read ↗

Immunogenic Cell Death Genes Related Prognostic Biomarker in Hepatocellular CarcinomaSemantic proximity Read ↗

Molecular Subtypes Based on Disulfidptosis-related Genes and Tumor Microenvironment Infiltration Characterization in Hepatocellular CarcinomaSemantic proximity Read ↗

Deciphering m6A signatures in hepatocellular carcinoma: Single‐cell insights, immune landscape, and the protective role of IGFBP3Semantic proximity Read ↗

DNA damage repair-related gene signature can influence immune status and predict prognosis in hepatocellular carcinomaSemantic proximity Read ↗

A novel DNA damage and repair-related gene signature to improve predictive capacity of overall survival for patients with gliomas.Semantic proximity Read ↗

Integration of single-cell sequencing and drug sensitivity profiling reveals an 11-gene prognostic model for liver cancer.Semantic proximity Read ↗

Identification of a seven-gene signature predicting clinical outcome of liver cancer based on tumor mutational burdenSemantic proximity Read ↗

Personalized Therapies in Hepatocellular Carcinoma: Insights from a Disulfidptosis-Related SignatureSemantic proximity Read ↗

Construct a Five-gene Prognostic Model Involving T Cell Exhaustion and Metabolic Reprogramming for Predicting the Risk of Hepatocellular Carcinoma using LASSO Algorithm: Insights into Immune Infiltration and Drug SensitivitySemantic proximity Read ↗

A Novel Prognostic Signature for Combined T-cell Exhaustion and Mitochondrial Dysfunction in Hepatocellular CarcinomaSemantic proximity Read ↗

DNA Damage Repair Profiles Alteration Characterize a Hepatocellular Carcinoma Subtype With Unique Molecular and Clinicopathologic FeaturesSemantic proximity Read ↗

M6a Regulator-Associated Methylation Modification Patterns Shape Tumor Microenvironment Characteristics in Hepatocellular CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.