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A demethylation-driven gene signature predicts prognosis and therapeutic vulnerability in hepatocellular carcinoma.

Scientific reports - 26 Feb 2026

Wang Zhengwei, Shi Lei, Li Yongjian, Liu Sikai, Shi Wanyin

Abstract excerpt

To develop and validate a demethylation-driven gene signature for predicting HCC prognosis, immune microenvironment features, and therapeutic vulnerabilities. We integrated transcriptomic data from TCGA-LIHC (n = 346 tumors) and GEO-GSE112790 (n = 183 tumors) with a curated list of 3,743 demethylation-related genes (DRGs). Tumor-associated DRGs were identified via differential expression analysis and WGCNA. A...

Topics

Humans
Liver Neoplasms
Carcinoma, Hepatocellular
Prognosis
Gene Expression Regulation, Neoplastic
Gene Expression Profiling
Transcriptome
Biomarkers, Tumor
Demethylation
DNA Methylation
Tumor Microenvironment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

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Open in PubMed Open full text

Identifiers

PMID: 41748810
DOI: 10.1038/s41598-026-41443-0
PMCID: PMC13046747

Genes

G6PD
CDC20
CEP41
SPINDOC
SUB1
TP53
VPS72

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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