Article
HDAC3 Serine 424 Phospho-mimic and Phospho-null Mutants Bidirectionally Modulate Long-Term Memory Formation and Synaptic Plasticity in the Adult and Aging Mouse Brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Jul 2025
Rodriguez Alyssa C, Kramár Eniko A, Augustynski Agatha S, Keiser Ashley A, Dong Tri N, Jones Tamara S, Vakilian Shanya N, Patel Sasha T, Rounds Jacob S, Chinn Carlene A, Kwapis Janine L, Matheos Dina P, Wood Marcelo A
Abstract excerpt
Long-term memory (LTM) formation is negatively regulated by histone deacetylase 3 (HDAC3), a transcriptional repressor. Emerging evidence suggests that posttranslational phosphorylation of HDAC3 at its serine 424 (S424) residue is critical for its deacetylase activity in transcription. However, it remains unknown if HDAC3 S424 phosphorylation regulates the ability of HDAC3 to modulate LTM formation. To examine...
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