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Article

Evolutionary dynamics of heparan sulfate utilization by SARS-CoV-2.

mBio - 13 Aug 2025

Higuchi Shuhei, Liu Yafei, Shimizu Jun, Ono Chikako, Itoh Yumi, Nakai Wataru, Jin Hui, Kishida Kazuki, Takayama Kazuo, Okamoto Toru, Murakami Yoshiko, Kinoshita Taroh, Matsuura Yoshiharu, Shioda Tatsuo, Arase Hisashi

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants have acquired enhanced infectivity compared to earlier variants. To elucidate the underlying molecular mechanisms, we conducted CRISPR library screening to identify cell surface molecules that interact with the Omicron spike protein. Our findings revealed a significantly higher affinity between the Omicron spike and cell surface heparan...

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Identifiers

PMID: 40548749
DOI: 10.1128/mbio.01303-25
PMCID: PMC12345153

Genes

TMPRSS2
ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

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