Article

In Vitro and Viral Evolution Convergence Reveal the Selective Pressures Driving Omicron Emergence

2025-04-24

Abstract excerpt

In vitro protein evolution provides powerful insights into the amino acid sequences that underlie key biological functions. Here, we used this approach to explore the evolutionary trajectories of the SARS-CoV-2 spike protein receptor-binding domain (RBD) constrained to engage the human ACE2 receptor—an essential first step in viral infection. Applying mild (LSS) or stringent (HSS) selection pressures starting from...

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Literature Corpus work: 1629d502-b628-5766-93a2-4116efbb8a8b
DOI: 10.1101/2025.04.23.650148

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