Article

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

2020-08-17

Abstract excerpt

We show that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain. Docking studies suggest a putative heparin/heparan sulfate-binding site adjacent to the domain that binds to ACE2. In vitro, binding of ACE2 and heparin to spike protein ectodomains occurs independently and a ternary complex can be generated using heparin...

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Literature Corpus work: dd530990-2afb-5306-a240-3939ff78fbc7
DOI: 10.2139/ssrn.3657535

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