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Spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice

29 Aug 2022

Abstract excerpt

Despite being more transmissible, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant only causes milder diseases in laboratory animals, often accompanied by a lower viral load compared with previous variants of concern. In this study, we report the structural basis for a robust interaction between the receptor-binding domain of the Omicron spike protein and mouse ACE2. We show that...

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PMID: 36075211
DOI: 10.1016/j.celrep.2022.111359

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