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The Evolution of Parkinson’s Disease Diagnostic Criteria and Biological Classification Systems

2026-08-27

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<h4>Background: </h4> Parkinson's disease (PD) diagnostic approaches have evolved substantially over the past two centuries in parallel with advances in clinical neurology, neuropathology, neuroimaging, genetics, and biomarker science. Recent developments, particularly α-synuclein(αSyn)-based biomarkers, have challenged traditional symptom-based definitions and enabled biologically driven disease classification. <...

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Literature Corpus work: 5e6c0f52-ca8b-5dfe-98ed-642f09cbf3ce
DOI: 10.20944/preprints202608.2012.v1

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