Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of Somatic Mutations in Primary Squamous Cell Carcinomas of the Hypopharynx and the Esophagus Developed in Individual Patients.

Head & neck - 1 Nov 2025

Matsui Hidetoshi, Eguchi Hidetaka, Okazaki Yasushi, Hirayama Yuji, Nibu Ken-Ichi, Shinomiya Hirotaka

Abstract excerpt

BACKGROUND: Hypopharyngeal squamous cell carcinoma (HPSCC) and esophageal squamous cell carcinoma (ESCC) share common risk factors such as alcohol consumption and smoking, leading to synchronous or metachronous diseases. METHODS: We analyzed 24 formalin-fixed paraffin-embedded tissue specimens of surgically treated HPSCC and ESCC from 12 Japanese patients. Targeted sequencing of 409 cancer-related genes was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase, Mitochondrial
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Esophageal Neoplasms

Share to Esophageal Squamous Cell Carcinoma

Share to Neoplasms, Multiple Primary

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 40536086
DOI: 10.1002/hed.28220

Genes

ALDH2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparison of Somatic Mutations in Primary Squamous Cell Carcinomas of the Hypopharynx and the Esophagus Developed in Individual Patients.PMID 40536086Read ↗

TP53 mutations in head and neck cancer.Semantic proximity Read ↗

The prognostic value of TP53 mutations in hypopharyngeal squamous cell carcinoma.Semantic proximity Read ↗

Systematic Review and Meta-analysis of the Most Common Genetic Mutations in Esophageal Squamous Cell Carcinoma.Semantic proximity Read ↗

Clonal relationship and alcohol consumption-associated mutational signature in synchronous hypopharyngeal tumours and oesophageal squamous cell carcinoma.Semantic proximity Read ↗

Profile of esophageal squamous cell carcinoma mutations in Brazilian patients.Semantic proximity Read ↗

Alcohol Consumption, ALDH2 Polymorphism as Risk Factors for Upper Aerodigestive Tract Cancer Progression and PrognosisSemantic proximity Read ↗

Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population.Semantic proximity Read ↗

Somatic mutations in oral squamous cell carcinomas in 98 Japanese patients and their clinical implications.Semantic proximity Read ↗

Susceptibility of Multiple Primary Cancers in Patients With Head and Neck Cancer: Nature or Nurture?Semantic proximity Read ↗

TP53 Mutations in Esophageal Squamous Cell Carcinoma.Semantic proximity Read ↗

Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinomaSemantic proximity Read ↗

p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.