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Article

p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma.

Cancer letters - 18 Mar 2007

Yokoyama Akira, Omori Tai, Tanaka Yoichi, Yokoyama Tetsuji, Sugiura Hitoshi, Mizukami Takeshi, Matsushita Sachio, Higuchi Susumu, Maruyama Katsuya, Ishii Hiromasa, Hibi Toshifumi

Abstract excerpt

Synchronous multiple intra-esophageal squamous cell carcinomas (SCCs) or oropharyngolaryngeal SCCs are common in alcoholics with esophageal SCC, and more frequently found in those with inactive heterozygous aldehyde dehydrogenase-2 (ALDH2). p53 alterations have been suspected as key molecular events in such multifocal esophageal carcinogenesis. We studied 95 Japanese alcoholic men with Tis and mucosal invasive...

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Source

Identifiers

PMID: 16759795
DOI: 10.1016/j.canlet.2006.05.004

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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