Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early Cognitive, Structural, and Microstructural Changes in Presymptomatic C9orf72 Carriers Younger Than 40 Years.

JAMA neurology - 1 Feb 2018

Bertrand Anne, Wen Junhao, Rinaldi Daisy, Houot Marion, Sayah Sabrina, Camuzat Agnès, Fournier Clémence, Fontanella Sabrina, Routier Alexandre, Couratier Philippe, Pasquier Florence, Habert Marie-Odile, Hannequin Didier, Martinaud Olivier, Caroppo Paola, Levy Richard, Dubois Bruno, Brice Alexis, Durrleman Stanley, Colliot Olivier, Le Ber Isabelle

Abstract excerpt

Importance: Presymptomatic carriers of chromosome 9 open reading frame 72 (C9orf72) mutation, the most frequent genetic cause of frontotemporal lobar degeneration and amyotrophic lateral sclerosis, represent the optimal target population for the development of disease-modifying drugs. Preclinical biomarkers are needed to monitor the effect of therapeutic interventions in this population. Objectives: To assess the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asymptomatic Diseases
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to C9orf72 Protein

Share to Cognition Disorders

Share to Image Processing, Computer-Assisted

Share to Magnetic Resonance Imaging

Share to Neuropsychological Tests

Share to White Matter

Source

Open in PubMed Open full text

Identifiers

PMID: 29197216
DOI: 10.1001/jamaneurol.2017.4266
PMCID: PMC5838615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early Cognitive, Structural, and Microstructural Changes in Presymptomatic C9orf72 Carriers Younger Than 40 Years.PMID 29197216Read ↗

Neurite density is reduced in the presymptomatic phase ofC9orf72diseaseSemantic proximity Read ↗

Pre-symptomatic radiological changes in frontotemporal dementia: propagation characteristics, predictive value and implications for clinical trials.Semantic proximity Read ↗

Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis.Semantic proximity Read ↗

Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics.Semantic proximity Read ↗

Deficits in verbal fluency in presymptomatic C9orf72 mutation gene carriers-a developmental disorder.Semantic proximity Read ↗

Presymptomatic studies in genetic frontotemporal dementiaSemantic proximity Read ↗

Longitudinal behavioral and neuropsychiatric changes and their MRI correlates in predementia C9orf72 and GRN mutation carriers.Semantic proximity Read ↗

Loss of brainstem white matter predicts onset and motor neuron symptoms in C9orf72 expansion carriers: a GENFI study.Semantic proximity Read ↗

Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriersSemantic proximity Read ↗

Widespread structural brain involvement in ALS is not limited to the C9orf72 repeat expansion.Semantic proximity Read ↗

MRI-based classifier to identify close-to-onset cases in <i>C9orf72</i> genetic frontotemporal dementiaSemantic proximity Read ↗

C9orf72-related disorders: expanding the clinical and genetic spectrum of neurodegenerative diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.