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Social isolation, loneliness, genetic risk, and incident dementia in people with type 2 diabetes mellitus: A population-based cohort study.

Journal of Alzheimer's disease : JAD - 1 Jul 2025

He Zhixuan, Nie Yu, Zhang Weijie, Liu Yue, Liu Yaping, Xue Huachen, Ai Sizhi, Feng Hongliang, Zhou Yujing, Zhang Jihui, Liang Yan Yannis, Ning Yuping

Abstract excerpt

BackgroundSocial isolation and loneliness, two independent constructs of social disengagement, are becoming increasingly recognized factors for dementia risk.ObjectiveWe aimed to investigate whether these two constructs also associate with dementia risk in individuals with type 2 diabetes mellitus (T2DM), which is becoming more prevalent.MethodsThe longitudinal study included 24,986 participants (mean age:...

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PMID: 40438953
DOI: 10.1177/13872877251344253

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APOE

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