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Association of social isolation, loneliness and genetic risk with incidence of dementia: UK Biobank Cohort Study

1 Feb 2022

Abstract excerpt

BACKGROUND: Social isolation and loneliness have been associated with increased risk of dementia, but it is not known whether this risk is modified or confounded by genetic risk of dementia. METHODS: We used the prospective UK Biobank study with 155 070 participants (mean age 64.1 years), including self-reported social isolation and loneliness. Genetic risk was indicated using the polygenic risk score for...

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PMID: 35197341
DOI: 10.1136/bmjopen-2021-053936

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