Article
Improved tumor-type informed compared to tumor-informed mutation tracking for ctDNA detection and microscopic residual disease assessment in epithelial ovarian cancer.
Journal of experimental & clinical cancer research : CR - 12 Jun 2025
Ben Sassi Mehdi, Azais Henri, Marcaillou Charles, Guibert Sylvain, Martin Emmanuel, Alexandre Jérôme, Benoit Louise, de Reynies Aurélien, Laude Emilie, Duong Cam, Medioni Jacques, Borghese Bruno, Bats Anne-Sophie, Taly Valerie, Laurent-Puig Pierre
Abstract excerpt
BACKGROUND: Epithelial ovarian cancer (EOC) is a leading cause of cancer mortality in women, often diagnosed at advanced stages. While first-line treatments improve survival, relapses remain common, with 5-year survival rates below 40%. Circulating tumor DNA (ctDNA) is a promising biomarker for non-invasive EOC detection and monitoring. It may help assess treatment response, notably microscopic residual disease....
Read the complete abstract on PubMedTopics
- Humans
- Female
- Circulating Tumor DNA
- Carcinoma, Ovarian Epithelial