Improved breast cancer risk prediction using chromosomal-scale length variation.

Abstract excerpt

INTRODUCTION: Early diagnosis of breast cancer leads to higher long-term survival rates. The development of a germline genetic test, or polygenic risk score, to identify women at high risk of breast cancer holds the potential to reduce cancer deaths. However, current tests based on SNPs do not perform much better than predictions based on family history and perform significantly worse in populations with...

Topics

• Humans
• Breast Neoplasms
• Female
• Genetic Predisposition to Disease
• Polymorphism, Single Nucleotide
• Multifactorial Inheritance
• Risk Factors