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Article

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors.

Oncotarget - 10 Jun 2025

Qian Helen, Ali Heba, Karri Vivekanudeep, Low Justin T, Ashley David M, Heimberger Amy B, Godley Lucy A, Sonabend Adam M, Dmello Crismita

Abstract excerpt

The CHEK2 gene serves a canonical role in the DNA damage response (DDR) pathway encoding the regulatory kinase CHK2 in the homologous recombination (HR) repair of double-strand breaks (DSB). Although CHEK2 is traditionally considered a tumor suppressor gene, recent studies suggest additional functions. Across several cohort studies, CHEK2 expression was negatively correlated with the efficacy of immune checkpoint...

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Share to Checkpoint Kinase 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immune Checkpoint Inhibitors

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Source

Open in PubMed Open full text

Identifiers

PMID: 40492861
DOI: 10.18632/oncotarget.28740
PMCID: PMC12151402

Genes

CHEK2
CHEK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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