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A telomere-associated molecular landscape reveals immunological, microbial, and therapeutic heterogeneity in colorectal cancer

26 May 2025

Abstract excerpt

Background: Colorectal cancer (CRC) ranks among the most prevalent malignancies of the gastrointestinal tract and remains a leading cause of cancer-related mortality worldwide. Although telomere biology has been increasingly implicated in immune modulation and tumor progression, its clinical significance in CRC remains poorly understood. Methods: We developed a telomere score, termed TELscore, by integrating...

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PMID: 40492114
DOI: 10.3389/fmolb.2025.1615533

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