A glutamine metabolism gene signature with prognostic and predictive value for colorectal cancer survival and immunotherapy response

Abstract excerpt

Background: Colorectal cancer (CRC) remains a major cause of cancer mortality, and dysregulated glutamine metabolism has emerged as a potential therapeutic target. However, the precise role of glutamine in CRC progression and treatment response remains debated. Methods: The authors collected transcriptome and microbiome information, from multiple sources to construct the GLMscore, a prognostic signature in CRC....

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