Article
CNTD1 is crucial for crossover formation in female meiosis and for establishing the ovarian reserve
20 May 2025
Abstract excerpt
In meiotic prophase I, hundreds of DNA double-strand breaks are formed and subsequently repaired as noncrossovers or crossovers (COs). COs are essential for accurate chromosome segregation during the first meiotic division, and errors in this process result in aneuploidy, birth defects, or infertility. Such errors are more pronounced in females compared with males, indicating that CO regulation and surveillance...
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