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Article

COSA-1 reveals robust homeostasis and separable licensing and reinforcement steps governing meiotic crossovers.

Cell - 30 Mar 2012

Yokoo Rayka, Zawadzki Karl A, Nabeshima Kentaro, Drake Melanie, Arur Swathi, Villeneuve Anne M

Abstract excerpt

Crossovers (COs) between homologous chromosomes ensure their faithful segregation during meiosis. We identify C. elegans COSA-1, a cyclin-related protein conserved in metazoa, as a key component required to convert meiotic double-strand breaks (DSBs) into COs. During late meiotic prophase, COSA-1 localizes to foci that correspond to the single CO site on each homolog pair and indicate sites of eventual...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22464324
DOI: 10.1016/j.cell.2012.01.052
PMCID: PMC3339199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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