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Structural insights into tRNA recognition of the human FTSJ1-THADA complex

7 Jun 2025

Abstract excerpt

tRNA undergoes various post-transcriptional modifications in the anticodon loop. FTSJ1, a protein conserved among most eukaryotes, mediates 2'-O-methylations at position 32 (Nm32) or position 34 (Nm34), complexed with THADA or WDR6, respectively. These methylations are crucial for accurate translation and cellular growth. FTSJ1 mutations are associated with non-syndromic X-linked intellectual disability. Although...

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PMID: 40483304
DOI: 10.1038/s42003-025-08278-3

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