Article

The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance

2021-02-08

Abstract excerpt

<h4>ABSTRACT</h4> FTSJ1 is a conserved human 2’-O-methyltransferase (Nm-MTase) that modifies several transfer RNAs (tRNAs) at position 32 and the wobble position 34 in the AntiCodon Loop (ACL). Its loss of function has been linked to Non-Syndromic X-Linked Intellectual Disability (NSXLID), and more recently to cancers. However, the molecular mechanisms underlying these pathologies are currently unclear. Here we r...

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Literature Corpus work: 9bccd7cc-1331-55b8-944b-fb5d2b603c8e
DOI: 10.1101/2021.02.06.430044

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