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Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism

3 Nov 2021

Abstract excerpt

Nearly all human complex traits and diseases exhibit some degree of sex differences, with epigenetics being one of the main contributing factors. Various tissues display sex differences in DNA methylation; however, this has not yet been explored in skeletal muscle, despite skeletal muscle being among the tissues with the most transcriptomic sex differences. For the first time, we investigated the effect of sex on...

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PMID: 34732242
DOI: 10.1186/s13148-021-01188-1

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