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Article

SNACS: a tool for demultiplexing single-cell DNA sequencing data.

Bioinformatics (Oxford, England) - 2 Jun 2025

Kennedy Vanessa E, Roy Ritu, Peretz Cheryl A C, Koh Andrew, Tran Elaine, Smith Catherine C, Olshen Adam B

Abstract excerpt

MOTIVATION: Single-cell DNA sequencing (scDNA-seq) and multi-modal profiling with the addition of cell-surface antibodies (scDAb-seq) have recently provided key insights into cancer heterogeneity. Scaling these technologies across large patient cohorts, however, is cost and time prohibitive. Multiplexing, in which cells from unique patients are pooled into a single experiment, offers a possible solution. While...

Read the complete abstract on PubMed

Topics

Single-Cell Analysis
Humans
Sequence Analysis, DNA
Polymorphism, Single Nucleotide
Software
High-Throughput Nucleotide Sequencing

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Leukemia

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Identifiers

PMID: 40471703
DOI: 10.1093/bioinformatics/btaf265
PMCID: PMC12208073

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