demuxSNP: supervised demultiplexing single-cell RNA sequencing using cell hashing and SNPs.

Abstract excerpt

BACKGROUND: Multiplexing single-cell RNA sequencing experiments reduces sequencing cost and facilitates larger-scale studies. However, factors such as cell hashing quality and class size imbalance impact demultiplexing algorithm performance, reducing cost-effectiveness. FINDINGS: We propose a supervised algorithm, demuxSNP, which leverages both cell hashing and genetic variation between individuals...

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