Article

Functional properties of a disease mutation for migraine in Kv2.1/6.4 channels

2024-07-11

Abstract excerpt

Voltage-gated potassium (Kv) channels are integral to cellular excitability, impacting the resting membrane potential, repolarization, and shaping action potentials in neurons and cardiac myocytes. Structurally, Kv channels are homo or heterotetramers comprising four α-subunits, each with six transmembrane segments (S1-S6). Silent Kv (KvS), includes Kv5.1, Kv6.1-6.4, Kv8.1-8.2, and Kv9.1-9.3, they do not form func...

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Literature Corpus work: 8ab42470-c586-56a0-aef6-7cb8f6e3801a
DOI: 10.1101/2024.07.08.602400

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