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Identification of sporulation genes in Bacillus anthracis highlights similarities and significant differences with Bacillus subtilis.

PLoS biology - 1 Dec 2025

Ramírez-Guadiana Fernando H, Brogan Anna P, Yu Yuanchen, Midonet Caroline, Sher Joel W, Schmid Ernst W, Roney Ian J, Rudner David Z

Abstract excerpt

The molecular basis of endospore formation in the model gram-positive bacterium Bacillus subtilis has been investigated for over half a century. Here, using high throughput and classical genetic approaches, we performed a comparative analysis of sporulation in the human pathogen Bacillus anthracis. A transposon-sequencing screen identified >150 genes required for B. anthracis sporulation. As anticipated, many of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41385520
DOI: 10.1371/journal.pbio.3003521
PMCID: PMC12700454

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