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Article

NXPH4 coordinates DNA repair and macrophage polarization to promote chemoresistance in colorectal cancer

2026-09-01

Abstract excerpt

<title>Abstract</title> <p>Chemoresistance remains a major barrier to effective treatment of advanced colorectal cancer (CRC). Neurexophilin-4 (NXPH4), a secreted glycoprotein linked to tumor progression, has not been mechanistically defined in CRC chemoresistance. We integrated transcriptomic datasets from chemotherapy-sensitive and -resistant CRC tissues and evaluated NXPH4 expression in clinical samples and CR...

Identifiers and source

Literature Corpus work
a9e300bb-effb-5351-b137-138345cd761c
DOI
10.21203/rs.3.rs-10604637/v1
Open publication

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NXPH4 coordinates DNA repair and macrophage polarization to promote chemoresistance in colorectal cancerDOI 10.21203/rs.3.rs-10604637/v1
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