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Article

G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway.

Nature cell biology - 1 Sept 2016

Cha Shih-Ting, Tan Ching-Ting, Chang Cheng-Chi, Chu Chia-Yu, Lee Wei-Jiunn, Lin Been-Zen, Lin Ming-Tsan, Kuo Min-Liang

Abstract excerpt

Epigenetic reprogramming has been associated with the functional plasticity of cancer-initiating cells (CICs); however, the regulatory pathway has yet to be elucidated. A siRNA screen targeting known epigenetic genes revealed that G9a profoundly impairs the chemo-resistance, self-renewal and metastasis of CICs obtained from patients with colorectal cancer (CRC). Patients with elevated G9a were shown to face a...

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PMID: 27525719
DOI: 10.1038/ncb3395

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CIC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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