Article
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer.
eLife - 26 May 2021
Sacchetti Andrea, Teeuwssen Miriam, Verhagen Mathijs, Joosten Rosalie, Xu Tong, Stabile Roberto, van der Steen Berdine, Watson Martin M, Gusinac Alem, Kim Won Kyu, Ubink Inge, Van de Werken Harmen Jg, Fumagalli Arianna, Paauwe Madelon, Van Rheenen Jacco, Sansom Owen J, Kranenburg Onno, Fodde Riccardo
Abstract excerpt
Phenotypic plasticity represents the most relevant hallmark of the carcinoma cell as it bestows it with the capacity of transiently altering its morphological and functional features while en route to the metastatic site. However, the study of phenotypic plasticity is hindered by the rarity of these events within primary lesions and by the lack of experimental models. Here, we identified a subpopulation of...
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