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The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent

29 Oct 2009

Abstract excerpt

An RNA-dependent RNA polymerase (RdRp) is the central catalytic subunit of the RNA-synthesizing machinery of all positive-strand RNA viruses. Usually, RdRp domains are readily identifiable by comparative sequence analysis, but biochemical confirmation and characterization can be hampered by intrinsic protein properties and technical complications. It is presumed that replication and transcription of the...

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PMID: 19875418
DOI: 10.1093/nar/gkp904

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