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Article

New nsp8 isoform suggests mechanism for tuning viral RNA synthesis

1 Feb 2010

Abstract excerpt

During severe acute respiratory syndrome coronavirus (SARS-CoV) infection, the activity of the replication/transcription complexes (RTC) quickly peaks at 6 hours post infection (h.p.i) and then diminishes significantly in the late post-infection stages. This "down-up-down" regulation of RNA synthesis distinguishes different viral stages: primary translation, genome replication, and finally viron assembly....

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PMID: 21203988
DOI: 10.1007/s13238-010-0028-8

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