Article

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

2020-08-14

Abstract excerpt

<h4>Background</h4> Evidence for aspirin’s chemopreventative properties on colorectal cancer (CRC) is substantial, but its mechanism of action is not well-understood. We combined a proteomic approach with Mendelian randomization (MR) to identify possible new aspirin targets that decrease CRC risk. <h4>Methods</h4> Human colorectal adenoma cells (RG/C2) were treated with aspirin (24 hours) and a stable isotope la...

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Literature Corpus work: aed57c25-94d1-57fa-86f5-fa4b05b230c0
DOI: 10.1101/2020.08.14.239871

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