Article

Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention

2024-11-23

Abstract excerpt

<h4>Background</h4> Preclinical, observational, and genetic epidemiological evidence implicate circulating lipids in cancer development. The role of approved and emerging lipid-perturbing medications in cancer risk is unclear. <h4>Patients and methods</h4> We employed cis -Mendelian randomization (MR) and colocalisation to evaluate the role of 5 lipid-perturbing drug targets (ANGPTL3, ANGPTL4, APOC3, CETP, PCSK9)...

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Literature Corpus work: 2d8b3dbd-cf0b-52e2-a635-015ae25862bf
DOI: 10.1101/2024.11.20.24317649

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