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New insights from Whole Genome Sequencing: BCLAF1 deletion as a structural variant that predisposes cells towards cellular transformation.

Oncology reports - 1 Oct 2021

Mwapagha Lamech M, Chibanga Vimbaishe, Shipanga Hendrina, Parker M Iqbal

Abstract excerpt

Cancer arises from a multi‑step cellular transformation process where some mutations may be inherited, while others are acquired during the process of malignant transformation. Aberrations in the BCL2 associated transcription factor 1 (BCLAF1) gene have previously been identified in patients with cancer and the aim of the present study was to identify structural variants (SVs) and the effects of BCLAF1 gene...

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Identifiers

PMID: 34490482
DOI: 10.3892/or.2021.8180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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