WT EGFR and the oncogenic mutant EGFR (L858R) employ distinct mechanisms for export from the endoplasmic reticulum, a process critical for their activation.

Abstract excerpt

The epidermal growth factor receptor (EGFR) is critical for cell differentiation, growth, proliferation, and migration. To function, newly synthesized EGFR must be transported from the endoplasmic reticulum (ER) to the cell surface, yet the specific molecular mechanisms mediating this trafficking are not fully understood. We found that the ER export of EGFR is facilitated by a conserved polyarginine (polyR) motif...

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