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Article

AGR2 Gene Function Requires a Unique Endoplasmic Reticulum Localization Motif

20 Dec 2011

Abstract excerpt

Soluble proteins are enriched in the endoplasmic reticulum (ER) by retrograde transport from the Golgi that is mediated by the KDEL receptors. In addition to the classic carboxyl-terminal KDEL motif, a variety of sequence variants are also capable of receptor binding that result in ER localization. Although different ER localization signals that exhibit varying affinities for the KDEL receptors exist, whether...

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PMID: 22184114
DOI: 10.1074/jbc.m111.301531

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