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Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses

7 Jul 2025

Abstract excerpt

Embryonic stem cells (ESCs) display a distinctive resistance against various viruses, irrespective of any interferon response. Nevertheless, the underlying mechanism of this resistance remains unclear. In this study, we identify vesicle-associated membrane protein 5 (VAMP5) as a potent cell-autonomous defense factor against coronaviruses, including SARS-CoV-2, with high expression levels observed in ESCs and...

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PMID: 40624080
DOI: 10.1038/s41467-025-61655-8

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