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Article

P2X7 receptor induces microglia polarization to the M1 phenotype in cancer-induced bone pain rat models.

Molecular pain - 1 Jan 2000

Wu Ping, Zhou Guohua, Wu Xiaoqi, Lv Run, Yao Jiaqi, Wen Qingping

Abstract excerpt

BACKGROUND: The transition from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype presents a novel therapeutic strategy for chronic pain. OBJECTIVE: We investigated the role of microglia polarization in cancer-induced bone pain (CIBP), as well as the role of the P2X7 receptor in modulating M1 to M2 polarization. METHODS: Walker-256 breast cancer cells were administered into tibias of female rats to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35057643
DOI: 10.1177/17448069211060962
PMCID: PMC8961217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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