Article
Xgr is involved in body size control in Drosophila through promoting glucose uptake in the Malpighian tubules.
Journal of genetics and genomics = Yi chuan xue bao - 1 Feb 2026
Lin Zhiwei, He Zihao, Guo Jianfeng, Ji Xiaofang, Hu Ze, Tang Yingsen, Wei Chuanxian, Liu Jiyong, Wu Wenqi, Ma Jun, Jiao Renjie
Abstract excerpt
Body size control is fundamental to development and requires proper energy engagement. One of the key energy sensing factors is AMP-activated protein kinase (AMPK), which regulates glucose uptake to ensure ATP production and nutrition supply during development. Here, we identify that the mutation of xgr, a gene encoding an ATPase, results in a reduced body size in Drosophila. Xgr is primarily expressed in the...
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