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Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.

PLoS genetics - 1 Aug 2016

Ishii Tasuku, Funato Yosuke, Hashizume Osamu, Yamazaki Daisuke, Hirata Yusuke, Nishiwaki Kiyoji, Kono Nozomu, Arai Hiroyuki, Miki Hiroaki

Abstract excerpt

Mg2+ serves as an essential cofactor for numerous enzymes and its levels are tightly regulated by various Mg2+ transporters. Here, we analyzed Caenorhabditis elegans strains carrying mutations in genes encoding cyclin M (CNNM) Mg2+ transporters. We isolated inactivating mutants for each of the five Caenorhabditis elegans cnnm family genes, cnnm-1 through cnnm-5. cnnm-1; cnnm-3 double mutant worms showed various...

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PMID: 27564576
DOI: 10.1371/journal.pgen.1006276
PMCID: PMC5001713

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