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Article

Type III interferon, age and IFNL gene single nucleotide polymorphisms determine the characteristics of H1N1 influenza infection

14 May 2025

Abstract excerpt

Background: Host factors, such as innate immune response, genetic polymorphisms, age, and body weight are important determinants of susceptibility, severity, and responsiveness to treatment of influenza disease. However, the molecular mechanisms underlying these clinical associations remain poorly characterized, particularly regarding IFN-λ-mediated antiviral responses. Methods: mice were used to systematically...

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PMID: 40438107
DOI: 10.3389/fimmu.2025.1592841

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