Article
IL-28B is a key regulator of B- and T-cell vaccine responses against influenza.
PLoS pathogens - 1 Dec 2014
Egli Adrian, Santer Deanna M, O'Shea Daire, Barakat Khaled, Syedbasha Mohammedyaseen, Vollmer Madeleine, Baluch Aliyah, Bhat Rakesh, Groenendyk Jody, Joyce Michael A, Lisboa Luiz F, Thomas Brad S, Battegay Manuel, Khanna Nina, Mueller Thomas, Tyrrell D Lorne J, Houghton Michael, Humar Atul, Kumar Deepali
Abstract excerpt
Influenza is a major cause of morbidity and mortality in immunosuppressed persons, and vaccination often confers insufficient protection. IL-28B, a member of the interferon (IFN)-λ family, has variable expression due to single nucleotide polymorphisms (SNPs). While type-I IFNs are well known to modulate adaptive immunity, the impact of IL-28B on B- and T-cell vaccine responses is unclear. Here we demonstrate that...
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