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Article

A novel genetic locus linked to pro-inflammatory cytokines after virulent H5N1 virus infection in mice

1 Jan 2014

Abstract excerpt

BACKGROUND: Genetic variation in the human population is a key determinant of influenza disease severity. A single nucleotide polymorphism in the antiviral gene IFITM3 was linked to outcomes during the 2009 H1N1 pandemic. To identify variant host genes associated with increased virus replication and severe disease, we performed a quantitative trait locus analysis on pro-inflammatory cytokine production 48 hours...

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PMID: 25418976
DOI: 10.1186/1471-2164-15-1017

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